Elastin Substructure, Elastogenesis and Elastolysis
نویسندگان
چکیده
منابع مشابه
The cell-elastin-elastase(s) interacting triade directs elastolysis.
Human elastases have been identified within serine, cysteine and metallopeptidase families. These enzymes are able to adsorb rapidly onto elastin, but they can also bind onto cell surface-associated proteins such as heparan sulfate proteoglycans, both interactions involving enzyme exosites distinct form active site. Immobilization of elastin at the cell surface will create a sequestered microen...
متن کاملElastin degradation by matrix metalloproteinases. Cleavage site specificity and mechanisms of elastolysis.
Insoluble elastin was used as a substrate to characterize the peptide bond specificities of human (HME) and mouse macrophage elastase (MME) and to compare these enzymes with other mammalian metalloproteinases and serine elastases. New amino termini detected by protein sequence analysis in insoluble elastin following proteolytic digestion reveal the P'1 residues in the carboxyl-terminal directio...
متن کاملElastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis.
OBJECTIVE Elastin, an extracellular matrix protein, constitutes about 30% of the dry weight of the arteries. Elastolysis induced by inflammatory processes is active in chronic arterial diseases. However, elastogenesis in arterial diseases has received little attention. In this work we hypothesized that disordered elastogenesis is active in matrix remodeling in atheroma and abdominal aortic aneu...
متن کاملGeneralized mid dermal elastolysis
Mid-dermal elastolysis (MDE) is a rare skin disorder clinically characterized by the appearance of diffuse fine wrinkling, most often of the trunk and arms. This entity is distinguished from other elastolytic disorders by its characteristic selective loss of elastic fibers of the mid dermis. The aetiopathogenesis of the disease is still unclear as well as the effective treatment. Half of the ca...
متن کاملDevelopment of a tropoelastin-binding MR contrast agent for in vivo imaging of impaired elastogenesis in atherosclerosis
Background Elastin is a primary component of the vessel wall and present in all elastic vessels such as the aorta and the pulmonary artery. Elastogenesis begins with the synthesis and secretion of the soluble precursor tropoelastin that becomes cross-linked into insoluble elastin. Under normal conditions cross-linked elastin is the only form of the molecule present in the vessel wall whereas tr...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1986
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.14.2_259